Research into Inflammatory Arthritis Centre Versus Arthritis [RACE]

2016 papers

Effect of IL-6 receptor blockade on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis

Welsh P, Tuckwell K, McInnes IB, Sattar N.

Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers

Brown PM, Pratt AG, Isaacs JD.

A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease

Hatterer E, Shang L, Simonet P, Herren S, Daubeuf B, Teixeira S, Reilly J, Elson G, Nelson R, Gabay C, Sokolove J, McInnes IB, Kosco-Vilbois M, Ferlin W, Monnet E, De Min C.

Differential impact of obesity on the pathogenesis of RA or preclinical models is contingent on the disease status

Kim SJ, Chen Z, Essani AB, Elshabrawy HA, Volin MV, Fantuzzi G, McInnes IB, Baker JF, Finn P, Kondos G, Volkov S, Swedler W, Arami S, Sweiss N, Shahrara S.

EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update

Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJ, Kvien TK, Dougados M, Radner H, Atzeni F, Primdahl J, Södergren A, Wallberg Jonsson S, van Rompay J, Zabalan C, Pedersen TR, Jacobsson L, de Vlam K, Gonzalez-Gay MA, Semb AG, Kitas GD, Smulders YM, Szekanecz Z, Sattar N, Symmons DP, Nurmohamed MT.

Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T cells partly via transforming growth factor-β1

Anderson AE, Swan DJ, Wong OY, Buck M, Eltherington O, Harry RA, Patterson AM, Pratt AG, Reynolds G, Doran JP, Kirby JA, Isaacs JD, Hilkens CM.

Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

Catherine E. Hughes, Robert A. Benson, Marija Bedaj, Pasquale Maffia

Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4+ T Cells

Maggi J, Schinnerling K, Pesce B, Hilkens CM, Catalán D, Aguillón JC.

Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis

Fisher BA, Donatien P, Filer A, Winlove CP, McInnes IB, Buckley CD, Taylor PC.

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL, Clark AR.

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

Lord P, Spiering R, Aguillon JC, Anderson AE, Appel S, Benitez-Ribas D, ten Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van Kooten C, Lopez Diaz de Cerio A, Nikolic T, Oral HB, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres EM, Hilkens CMU.

11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

Hardy RS, Doig CL, Hussain Z, O'Leary M, Morgan SA, Pearson MJ, Naylor A, Jones SW, Filer A, Stewart PM, Buckley CD, Lavery GG, Cooper MS, Raza K.

Why should rheumatologists care about fibroblasts?

Buckley CD

Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis

Clowse ME, Feldman SR, Isaacs JD, Kimball AB, Strand V, Warren RB, Xibillé D, Chen Y, Frazier D, Geier J, Proulx J, Marren A.

Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial

Porter D, van Melckebeke J, Dale J, Messow CM, McConnachie A, Walker A, Munro R, McLaren J, McRorie E, Packham J, Buckley CD, Harvie J, Taylor P, Choy E, Pitzalis C, McInnes IB.

Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance

Tibbitt C, Falconer J, Stoop J, van Eden W, Robinson JH, Hilkens CM.

MicroRNA-155/PU.1 axis influences B-cell function in rheumatoid arthritis 

Alivernini S, Kurowska-Stolarska M, Tolusso B, Benvenuto R, Elmesmari A, Canestri S, Petricca L, Mangoni A, Fedele AL, Di Mario C, Gigante MR, Gremese E, McInnes IB, Ferraccioli G.

MICL controls inflammation in rheumatoid arthritis 

Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, Wright J, Murray GI, Willment JA, Hocking LJ, Fernandes MJ, De Bari C, McInnes IB, Brown GD.

Components of treatment delay in rheumatoid arthritis differ according to autoantibody status: validation of a single-centre observation using national audit data

Pratt AG, Lendrem D, Hargreaves B, Aslam O, Galloway JB, Isaacs JD.

Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures

Nayar S, Campos J, Chung MM, Navarro-Núñez L, Chachlani M, Steinthal N, Gardner DH, Rankin P, Cloake T, Caamaño JH, McGettrick HM, Watson SP, Luther S, Buckley CD, Barone F.

MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis

Elmesmari A, Fraser AR, Wood C, Gilchrist D, Vaughan D, Stewart L, McSharry C, McInnes IB, Kurowska-Stolarska M.

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial

Li R, Zhao JX, Su Y, He J, Chen LN, Gu F, Zhao C, Deng XR, Zhou W, Hao YJ, Xue Y, Liu HX, Zhao Y, Zou QH, Liu XY, Zhu P, Sun LY, Zhang ZL, Zou HJ, Li XF, Liu Y, Fang YF, Keystone E, McInnes IB, Li ZG.

Predicting Functional Disability: One-Year Results From the Scottish Early Rheumatoid Arthritis Inception Cohort

Kronisch C, McLernon DJ, Dale J, Paterson C, Ralston SH, Reid DM, Tierney A, Harvie J, McKay N, Wilson HE, Munro R, Saunders S, Richmond R, Baxter D, McMahon M, Kumar V, McLaren J, Siebert S, McInnes IB, Porter D, Macfarlane GJ, Basu N.

Proatherogenic Cytokine Microenvironment in the Aortic Adventitia of Patients With Rheumatoid Arthritis

Ahmed A, Hollan I, Curran SA, Kitson SM, Riggio MP, Mikkelsen K, Almdahl SM, Aukrust P, McInnes IB, Goodyear CS.

Targeting ultrasound remission in early rheumatoid arthritis: the results of the TaSER study, a randomised clinical trial

Dale J, Stirling A, Zhang R, Purves D, Foley J, Sambrook M, Conaghan PG, van der Heijde D, McConnachie A, McInnes IB, Porter D.

Characteristics of rheumatoid arthritis and its association with major comorbid conditions: cross-sectional study of 502 649 UK Biobank participants

Siebert S, Lyall DM, Mackay DF, Porter D, McInnes IB, Sattar N, Pell JP.

Perceptions of risk and predictive testing held by the first-degree relatives of patients with rheumatoid arthritis in England, Austria and Germany: a qualitative study

Stack RJ, Stoffer M, Englbrecht M, Mosor E, Falahee M, Simons G, Smolen J, Schett G, Buckley CD, Kumar K, Hansson M, Hueber A, Stamm T, Raza K.

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures

Kremer JM, Lawrence DA, Hamilton R, McInnes IB.

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis

Plant D, Webster A, Nair N, Oliver J, Smith SL, Eyre S, Hyrich KL, Wilson AG, Morgan AW, Isaacs JD, Worthington J, Barton A.

Analysis of the cell populations composing the mononuclear cell infiltrates in the labial minor salivary glands from patients with rheumatoid arthritis and sicca syndrome

Fragoulis GE, Fragkioudaki S, Reilly JH, Kerr SC, McInnes IB, Moutsopoulos HM.

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Jani M, Isaacs JD, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A; BRAGGSS.

Comparative ability of mesenchymal stem cells from different tissues to limit neutrophil recruitment to inflamed endothelium

Munir H, Luu N-T, Nash GB, and McGettrick HM.

Drug breakthrough offers hope to arthritis sufferers: qualitative analysis of medical research in UK newspapers

Hanson H, O'Brien N, Whybrow P, Isaacs JD, Rapley T.

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort

Smith SL, Plant D, Lee XH, Massey J, Hyrich K, Morgan AW, Wilson AG, Isaacs J, Barton A.

Rheumatoid arthritis

Smolen JS, Aletaha D, McInnes IB.

Expression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis

Yeo L, Adlard N, Biehl M, Juarez M, Smallie T, Snow M, Buckley CD, Raza K, Filer A, Scheel-Toellner D.

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis 

Bell GM, Anderson AE, Diboll J, Reece R, Eltherington O, Harry RA, Fouweather T, MacDonald C, Chadwick T, McColl E, Dunn J, Dickinson AM, Hilkens CM, Isaacs JD.

Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging

Scales HE, Ierna M, Smith KM, Ross K, Meiklejohn GR, Patterson-Kane JC, McInnes IB, Brewer JM, Garside P, Maffia P.

A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases

Liu Y, Mu R, Gao YP, Dong J, Zhu L, Ma Y, Li YH, Zhang HQ, Han D, Zhang Y, McInnes IB, Zhang J, Shen B, Yang G, Li ZG.

IL-6 deriven STAT signalling in circulating CD4+ lymphocytes is a marker for early anti-citrullinated peptide antibody-negative rheumatoid arthritis

Anderson AE, Pratt AG, Sedhom M, Doran JP, Routledge C, Hargreaves B Brown PM, Isaacs JD, Thomas R.

CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3⁺ T Cells

Lipid Changes With Different Antiinflammatory Regimens in Rheumatoid Arthritis: Developing a Pragmatic Approach to Complex Data

Sattar N, McInnes IB.

Therapeutic Targeting of IL-17 and IL-23 Cytokines in Immune-Mediated Diseases

Fragoulis GE, Siebert S, McInnes IB.

DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system

Juarez M, McGettrick HM, Scheel-Toellner D, Yeo L, Spengler J, de Paz B, Hardy R, Cooper M, Raza K, Buckley CD, Filer A.

Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sjögren's syndrome: a pilot study

Lugonja B, Yeo L, Milward MR, Smith D, Dietrich T, Chapple IL, Rauz S, Williams GP, Barone F, de Pablo P, Buckley C, Hamburger J, Richards A, Poveda-Gallego A, Scheel-Toellner D, Bowman SJ.

Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors

Baik S, Sekai M, Hamazaki Y, Jenkinson WE, Anderson G.

Biosimilars in immune-mediated inflammatory diseases: initial lessons from the first approved biosimilar anti-tumour necrosis factor monoclonal antibody

Isaacs JD, Cutolo M, Keystone EC, Park W, Braun J.