RACE Publications

Female student standing reading a journal in the University library

  • Mirza, M., Siebert, S., Pratt, A., Insch, E., McIntosh, F., Paton, J., Wright, C., Buckley, CD., Isaacs, J., McInnes, IB., Raza, K., Falahee, M.  Impact of the COVID‐19 pandemic on recruitment to clinical research studies in rheumatology. Musculoskeletal Care, first published: 03 May 2021. doi: 10.1002/msc.1561
  • Nijjar JS, Morton FR, Bang H, Buckley CD, van der Heijde D, Gilmour A, Paterson C, McInnes IB, Porter D, Raza K. The impact of autoantibodies against citrullinated, carbamylated, and acetylated peptides on radiographic progression in patients with new-onset rheumatoid arthritis: an observational cohort study. Lancet Rheumatol 2021; 3: e284-293. Published:January 27, 2021. https://doi.org/10.1016/S2665-9913(20)30381-7
  • Schittenhelm L, Robertson J, Pratt AG, Hilkens CM, Morrison VL. Dendritic cell integrin expression patterns regulate inflammation in the rheumatoid arthritis joint. Rheumatology (Oxford). 2021 Mar 2;60(3):1533-1542. doi: 10.1093/rheumatology/keaa686. PMID: 33123735; PMCID: PMC7937020.

  • Kästele V, Mayer J, Lee ES, Papazian N, Cole JJ, Cerovic V, Belz G, Tomura M, Eberl G, Goodyear C, Maciewicz RA, Wall D, Cupedo T, Withers DR, Milling S. Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection. Mucosal Immunol 14, 717–727 (2021).  https://doi.org/10.1038/s41385-020-00366-3
  • Zemedikun DT, Gokhale K, Chandan JS, Copper J, Lord JM, Filer A, Falahee M, Nirantharakumar K, Raza K. Type 2 diabetes mellitus, glycaemic control, associated therapies and risk of rheumatoid arthritis: a retrospective cohort study. Rheumatology, 2021; doi: 10.1093/rheumatology/keab148
  • Pratt AG, Siebert S, Cole M, Stocken DD, Yap C, Kelly S, Shaikh M, Cranston A, Morton M, Walker J, Frame S, Ng W-F, Buckley CD, McInnes IB, Filer A, Isaacs JD. Targeting synovial fibroblast proliferation in rheumatoid arthritis (TRAFIC): an open-label, dose-finding, phase 1b trial.  Lancet Rheumatol 2021; 3: e337–46 Published Online March 9, 2021 https://doi.org/10.1016/ S2665-9913(21)00061-8
  • Wang, Y., Khan, A., Antonopoulos, A., Buckley, CD., Filer, A.,  Raza, K., Li K., Tolusso, B., Gremese, E., Kurowska-Stolarska, M., Alivernini, S., Dell, A., Pineda, MA. Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nat Commun 12, 2343 (2021). https://doi.org/10.1038/s41467-021-22365-z
  • Maney NJ, De Paula Lemos H, Barron-Millar B, Carey C, Herron I, Anderson AE, Mellor A, Isaacs JD, Pratt AG. Pim kinases are therapeutic targets in early rheumatoid arthritis. First published: 28 March 2021. Arthritis & Rheumatologyhttps://doi/10.1002/art.41744
  • Gray, J.I., Al‐Khabouri, S., Morton, F., Clambey, E.T., Gapin, L., Matsuda, J.L., Kappler, J.W., Marrack, P., Garside, P., Otto, T.D. and MacLeod, M.K. (2021), Tolerance induction in memory CD4 T cells is partial and reversible. Immunology, 162: 68-83. https://doi.org/10.1111/imm.13263
  • Ferguson LD, Linge J, Dahlqvist Leinhard O, Woodward R, Hall Barrientos P, Roditi G, Radjenovic A, McInnes IB, Siebert S, Sattar N. Psoriatic arthritis is associated with adverse body composition predictive of greater coronary heart disease and type 2 diabetes propensity – a cross-sectional study, Rheumatology, Volume 60, Issue 4, April 2021, Pages 1858–1862, doi:10.1093/rheumatology/keaa604
  • Al Khabouri, TS., Benson, RA., Prendergast, CT., Gray, JI., Otto, TD., Brewer, JM., Garside, P. CRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis. Front. Immunol., 27 April 2021. doi.org/10.3389/fimmu.2021.669856
  • Alivernini, S., MacDonald, L., Elmesmari, A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C, Bui L, Perniola S, Attar M, Gessi M, Fedele AL, Chilaka S, Somma D, Sansom SN, Filer A, McSharry C, Millar NL, Kirschner K, Nerviani A, Lewis MJ, Pitzalis C, Clark AR, Ferraccioli G, Udalova I, Buckley CD, Gremese E, McInnes IB, Otto TD, Kurowska-Stolarska M. Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nat Med 26, 1295–1306 (2020). https://doi.org/10.1038/s41591-020-0939-8
  • Baker KF, Thompson B, Lendrem DW, Scadeng A, Pratt AG, Isaacs JD. Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission. Therapeutic Advances in Musculoskeletal Disease. First Published May 11, 2020 Research Article. https://doi.org/10.1177/1759720X20915322
  • Siebert S, Pratt AG, Stocken DD, Morton M, Cranston A, Cole M, Frame S, Buckley CD, Ng WF, Filer A, McInnes IB, Isaacs JD. Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial. Medicine (Baltimore). 2020 Jun 26;99(26):e20458. doi: 10.1097/MD.0000000000020458. PMID: 32590730; PMCID: PMC7328978.
  • Penkava F, Velasco-Herrera MDC, Young MD, Yager N, Nwosu LN, Pratt AG, Lara AL, Guzzo C, Maroof A, Mamanova L, Cole S, Efremova M, Simone D, Filer A, Brown CC, Croxford AL, Isaacs JD, Teichmann S, Bowness P, Behjati S, Hussein Al-Mossawi M. Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat Commun 11, 4767 (2020). https://doi.org/10.1038/s41467-020-18513-6
  • Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. The Lancet Respiratory Medicine, Volume 8, Issue 8, 2020, Pages 822-830, ISSN 2213-2600, https://doi.org/10.1016/S2213-2600(20)30267-8.
  • Daly R, Blackburn G, Best C, Goodyear CS, Mudaliar M, Burgess K, Stirling A, Porter D, McInnes IB, Barrett MP, Dale J. Changes in Plasma Itaconate Elevation in Early Rheumatoid Arthritis Patients Elucidates Disease Activity Associated Macrophage Activation. Metabolites. 2020 Jun 10;10(6):24, doi: 10.3390/metabo10060241.
  • Fragoulis GE, Cavanagh J, Tindell A, Derakhshan M, Paterson C, Porter D, McInnes IB, Siebert S. Depression and anxiety in an early rheumatoid arthritis inception cohort. associations with demographic, socioeconomic and disease features. RMD Open 2020;6:e001376. doi: 10.1136/rmdopen-2020-001376
  • C Vinci, M Infantino, S Raturi, A Tindell, LM Topping, R Strollo, H Amital, Y Shoenfeld, S Gertel, V Grossi, M Manfredi, IM Rutigliano, F Bandinelli, F Li Gobbi, A Damiani, P Pozzilli, IB Mcinnes, CS Goodyear, M Benucci & A Nissim (2020) Immunoglobulin A antibodies to oxidized collagen type II as a potential biomarker for the stratification of spondyloarthritis from rheumatoid arthritis, Scandinavian Journal of Rheumatology, 49:4, 281-291, DOI: 10.1080/03009742.2020.1713395
  • Bywall KS, Kihlbom U, Hansson M, Falahee M, Raza K, Baecklund E, Veldwijk J. Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients. Arthritis Res Ther 22, 288 (2020). doi: 10.1186/s13075-020-02391-w
  • McIntyre CL, Monin L, Rop JC, Otto TD, Goodyear CS, Hayday AC, Morrison VL. β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance. Proceedings of the National Academy of Sciences Sep 2020, 117 (36) 22367-22377; DOI: 10.1073/pnas.1921930117
  • Pollock, J., Raza, K., Pratt, AG., Hanson, H., Siebert, S., Filer, A., Isaacs, JD., Buckley, CD., McInnes, IB., Falahee, M. Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research. Musculoskeletal Care, Vol 15, Issue 4, December 2017, Pp 395-399. doi: 10.1002/msc.1171